Anyone know why someone would have an adverse reaction to molybdenum?
- MTHFR c677t (++)
- CBS (+/-)
- BHMT 8 (+\-)
- MTR (+\-)
- COMT (+\-)
Her concerns are fatigue, memory, stamina and mood. History of hashimotos, better paleo and small amounts of sublingual B12.
Thanks for any suggestions,
Dr Lynch’s Response:
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There is a connection between copper and molybdenum.
Consider evaluating her copper levels.
Also – if her sulfur intake is not that high and her hydrogen sulfide production not that high, then molybdenum is not needed much beyond what she gets in her multi, diet, etc
She only is hetero for CBS – and you also didnt specify which CBS snp – 699 appears to be most related to an increase in CBS enzyme kinetics.
Increased oxidative stress increases CBS throughput even in the absence of a SNP. If her oxidative stress is not so bad, then the production of hydrogen sulfide and other sulfur is likely not so bad.
She also may be low in sulfur and glutathione which could aggravate with molybdenum potentially. This may allow the molybdenum to interact more freely with Cu if it doesnt have so much sulfur to work with. Theoretical…
and – not really related but potentially useful: