L-Methylfolate: What, When, Why and How

L-methylfolate is like a round wheel. Folic acid is like a square ‘wheel’. We’ve evolved. It’s time for folic acid to go away.

An Evolved Caveman

While this is indeed funny, it’s tragic.

Folic acid is basically a square wheel to your body. It has to be processed by many different enzymes so your body can turn it into a round wheel – L-methylfolate.

Why would you use a square ‘wheel’ when a round wheel is invented and readily available?

Learn about L-Methylfolate

Here is a great summary video

I will soon have this video transcribed as well for you. It is being worked on.

L-Methylfolate: What It Does

The job of L-Methylfolate is supporting methylation. (Learn more about methylation here.)

Without L-methylfolate available, your methylation cycle struggles. As a result, your homocysteine levels may climb up above 7. If your homocysteine is above 7, then you should be working on your methylation. (If your homocysteine is lower than 7, that’s a different story but it’s not ideal.)

Lowering your homocysteine with just L-methylfolate may work but unlikely. One needs to have adequate:

  • Methylcobalamin (vitamin B12)
  • TMG (Betaine)
  • Pyridoxine (vitamin B6)
  • Riboflavin (vitamin B2)

These nutrients typically suffice to help support healthy levels of homocysteine.

HomocysteX Plus contains these nutrients in one easy-to-swallow capsule.

L-Methylfolate: How it is Made

Making this is not easy.

There are many genes involved here and, yes, many of these genes can be problematic for people.

Look at this individual’s folate pathway genes. They are highly susceptible to low levels of L-methylfolate:

  • Folic acid starts at the top and has to go through each one of those genes
  • MTHFD1 gene is red so it is really reduced in function so it cannot easily convert folate into L-methylfolate
  • MTHFR gene is red so it is also very reduced in function so it cannot easily convert folate into L-methylfolate
  • Result? This individual could be quite low in L-methylfolate if not eating leafy green vegetables
  • Low l-methylfolate levels contribute to poorly functioning methylation and homocysteine levels increase

Want to see your Folate Pathway and Genetics? Order StrateGene to find out fast.

L-Methylfolate: I have MTHFR. Do I Need it?

So many people get their MTHFR test results back and find they have some form of MTHFR SNP.

This leads to the practitioner recommending high amounts of L-methylfolate.


One should never recommend a high amount of a supplement based on the MTHFR genetic test result alone. That’s not enough information.

What happens is commonly side effects and that’s not good.

L-methylfolate is a fantastic nutrient and it’s getting a bad rap because it’s not used properly.

It all depends on the person how much of any nutrient they need – not which SNP they have.

Now no one should take folic acid….

L-Methylfolate: How Much to Use?

This is a tricky question. It all depends on the person.

  • If not eating sufficient leafy green vegetables, you’ll need to take some.
  • Pregnant and breastfeeding? You’ll need it.
  • Growing child? Needs it
  • Elevated homocysteine? You’ll need it.

L-Methylfolate: Who Does Not Need It?

We all need some – all of us.

Those who do not that much more:

  • Eating sufficient green vegetables – with lunch and dinner AND
  • Healthy homocysteine level (between 6.5 and 8)

If this is you, you do not need that much more and maybe you don’t need any on some days. Some days I skip it completely and other days I need a few milligrams (when presenting at a conference for hours).

L-Methylfolate: Where to Get It?

You can find it in a number of different supplements currently. This is a great thing.

I’ve formulated a few different ways to take L-methylfolate supplements:

  • L-methylfolate lozenge: take a smaller amount easily, allow to dissolve slowly so you ‘feel’ when enough and take out the rest.
  • L-methylfolate liposomal: for those having difficulty absorbing L-methylfolate into the cell or need to give small amounts
  • L-methylfolate capsule: suited for those who know how much L-methylfolate they need and can quickly take and swallow it


L-Methylfolate and You

How is it helping you? Share your experiences.


Get Dr Lynch’s “26 Steps to Clean Genes”
Dr Lynch values your trust. We do not spam.

All emails include an unsubscribe link. You may opt-out at any time. See our privacy policy.

Comments 35

  1. Great information! A similar assessment of how folinic acid fits into the big picture would be most helpful, as well. Thanks!

    1. Post
      1. Yes, I would like this to as I discovered 4-5 years ago that I could well tolerate folinic acid yet taking any amount of supplemental methyl folate would create tension and sleeplessness. Fortunately on folinic acid red blood cell measures MCV and MCH normalized for the first time in the 30+ years I’ve been paying attention.

        1. Post
    1. Post


      When presenting, I am burning through my neurotransmitters like crazy and also needing to make more.

      The more you use your brain, the more folate you need.

      When on vacation, I use way less and many times only take my multivitamin a few days a week while on vacation.

    1. Post
    1. Post
  2. Where do you get blood test to find out more about B vitamins levels and any other important test to help supplement.Every time I take B 12 hydoxycobolamin methylcobalamin and methly-folate I get really sick and very weak headaches etc. I get scared and stop and then start back again taking very small doses not sure why am having such terrible reactions. I really need support no doctors in this area that understand. getting very frustrated with trying to figure out how to help myself I do have mthfr

    1. Post
  3. Are there not people (like me) who can not tolerate methyls at all and have no choice but to take folic acid? The body does have a folic acid receptor I thought as a separate cycle.

    1. Post
    1. Post
  4. I have learned so much from your videos! Thanks for your research and caring about helping others heal naturally, they way we were meant to heal.

    1. Post
  5. Very clear and succinct coverage of a complex issue. Thanks! The one case you didn’t note above is overly low homocysteine (e..g 0.1 – 6.0 ) Can you address this sometime — both causes and therapeutic approaches?

    1. Post
  6. I had colon cancer. I think it might have been due to the synthetic folic acid that I was taking when I was trying to get pregnant and expecting my son (I have a double MTHFR C677T defect). What type of supplement does someone like me need to deal with methylation problems?

    1. Post
  7. I was struggling under a long-lasting depression for about 3 years, trying everything I could besides pharmaceutical anti-depressants (last, last, last resort!), and my apothecary suggested I get on some B12 with 5-MTHF after he read that people experiencing depression often have elevated homocysteine levels in the blood. So I figured there was nothing to lose, and within DAYS I was feeling more myself again for the first time in years! I am so incredibly grateful to be able to *function* again! It’s a greater gift than I have words for…

    1. Post

      Awesome Leah! It is powerful stuff and works amazingly well and fast! Keep in mind that when you are feeling great, you may want to actually stop using it for a day or two – see how you feel. If you stay on it even though you feel great, you could actually become irritable and we don’t want that 😉 Talk with your doctor about it. I call this ‘pulsing’. Use the supplement as needed and stop when you don’t need it. I formulated a great lozenge which has both Active B12 with L-5-MTHF. It’s very popular and helps many quickly.

  8. My homocysteine is too high my folate, B12 & D3 levels are extremely low.
    I started taking D3 10,000 & a methyl basic B complex 400 mcg of
    L-5-Methyltetrahydrofolate At first the lethargy & fatigue started getting better. Now my fatigue is overwhelming. Do I need to take a lower dose?

  9. I’m homozygous 677, 2 years ago started experiencing this every other day fatigue – yes, one day I’d be 100% and the next headache, (adrenal?) fatigue type symptoms and the cycle goes on. Nothing including homocystex plus helped to break this alternate day fatigue / lathargy. My ‘off days’ are driving me up the wall. Any thoughts are appreciated!

  10. If an individual is homozygous for the A1298C gene is it necessary to supplement with methylfolate and or B12? Not all doctors are familiar with the MTHFR Gene and how to balance deficiencies. Thanks

    1. Post

      It depends on the individual. One who has MTHFR A1298C homozygous is more susceptible to being low in methylfolate but does not mean they are.

    1. Post

      Yes – it is important for folate too. There are no clinically relevant SNPs that I’ve found currently.

  11. Dr. Lynch I am compound hetro I found this out Aug of 2016 from a Boston heart diagnostic panel threw a functional np dr. I am seeing for a new thyroid issue. He had me take pure encapsulation homocystiene factors. That made me feel unwell. My blood foliate was 24. So I didn’t take anything for a while. Just betaine with pepsin. Healing from diverticulitis. I had a spectra cell nutrient panel done in March and I was only deficient in b6,vit a, d3 (42) k2, foliate and b12 was okay. Labs on b12 blood 900, without taking anyb12 for a year 1000 prior. So I ordered your optimal multi minus to try. Take it a few times a week seem to tolerate it better than pure encapsulation b complex to. My homocystiene went down from 10.1 to 7.7 in Feb with just getting foliate from veggies,and taking betaine hcl with pepsin, then it is up again from August lab 10.9 . So frustrating. Trying to understand.

  12. Good morning Dr Lynch , I just made the SAM/SAH test by health diagnostics but for 15 days before test I stopped my supplementations for methylation (b12, methylfolate ECC). Do you think the test will be very influenced and my methylation rate will be as I hadn’t never supplemented for improve methylation ?

  13. My sister recently found out she has thalassemia and her doctor recommended she take a folic acid supplement. I understand that she should NOT be taking folic acid, but if she is not getting enough folate in her diet would you recommend methylfolate for thalassemia?

  14. My daughter has POTS & MTHFR gene mutation – sorry, can’t find specifics – just found out her B6 is at 167. Normal range 2.0-32.0…so I’m freaking out! All of the side effects are the same as her POTS symptoms!

    She used to take Deplin 15mg but hasn’t for a year. Stopped B Complex & multi-vitamin- what else can we do?! Trying to learn everything I can. Thx!

Leave a Reply

Your email address will not be published. Required fields are marked *