23andMe v5 Chip: What You Need to Know

If there is one thing constant in life, it’s change.

23andMe has a new version 5 chip which has the genetic reporting industry all up in arms.

Here are some common questions along with answers. Note that 23andMe may change how things are done at any time thereby rendering this entire article irrelevant.

Does 23andMe still test for MTHFR in the raw data? 

Yes. Both MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) are there.

Can I access my raw data still?

Yes. You can access your raw data and download it as a .TXT file.

Which SNPs are missing from the new 23andme v5?

It depends on which genetic reporting tool you are using. Some reports are missing hundreds of SNPs. I say good riddance as most of those SNPs were likely irrelevant anyway. The presence of a SNP does not mean there is any variation of function – at all. People still are not getting this concept – and it is very frustrating.

The clinically-relevant SNPs no longer available in StrateGene:

  • rs72558181 MAT1A. This is quite rare anyhow in the population. Seeing how it is affected is possible in your StrateGene report. Testing for ‘Methionine’, ‘magnesium’ and ‘SAMe’ can be done to see if this gene is working as it should.

  • rs1799895 SOD3. Testing ‘lipid peroxidation’ can make up for this. Seeing how SOD is presented in StrateGene will offer some diagrammatic insights of how to support it.

  • rs1050450 GPX1. Testing ‘lipid peroxidation’ can make up for this. Test to see if your GPX is dirty here.

  • rs1800783 NOS3. If having cold hands and feet, that a dirty NOS3. Your StrateGene report will still provide  Test to see if your NOS3 is dirty here.

  • i6018900 SULT1A1. This hasn’t been called for some time. You should avoid food coloring, preservatives anyhow.

  • rs6323 MAOA. This is a bummer. Easy questions can determine if this gene is dirty or not. Use your StrateGene report to still provide you diagrammatic insights on how it works with other genes. Check to see if your MAOA is dirty and what to do about it.

  • rs1137070. MAOA. Same as above.

  • rs1799836. MAOB. Use your ‘Histamine Pathway’ in your StrateGene report to see what you can do to support it. Seeing if your ‘riboflavin’ levels are sufficient is important here.

  • rs10156191. AOC1/ABP1/DAO. If you have histamine intolerance from food or drink, then this gene is dirty – period. You don’t need a SNP to tell you this. See if your DAO gene is dirty and how to clean it up.

  • rs2228570. VDR. This is a touchy SNP in the first place and the information in published research is conflicting. Read this to learn more about vitamin D.

  • i3002468. HFE. Key here is to check your ‘serum ferritin’ and ‘TIBC’. This has to do with hemochromatosis which is quite common. Personally I have yet to see anyone with this SNP ++.

Should I order 23andMe still?

If you have not yet run 23andMe, you may still benefit from it if you are ok with not having the above SNPs in your results. It is still a good value for $99.

Is Ancestry.com a better option now?

No. I ran my Ancestry test and imported it into StrateGene. There were way more SNPs missing than 23andMe v5.

Which genetic testing reporting tool should I use?

I personally do not recommend using MTHFR Support, Livewello, Nutrahacker or Genetic Genie.

Why?

I do not agree with the SNPs they are calling as clinically-relevant nor do I agree with the recommendations provided.

StrateGene is the most researched, cited and actionable genetic testing report available. No it does not provide supplement recommendations. One cannot make recommendations based solely on a genetic report.

Promethease and Self Hacked are two other reporting companies that have researched information. Be cautious with any supplement recommendations made, however. I do not support that at all.

What is the long term solution?

I am currently working on a solution which will be vastly superior to both 23andMe and Ancestry. You can also be assured that it will maintain the strong clinically-relevant and published literature review requirements as the current StrateGene. The only difference? It will have more information and more relevant SNPs.

It is unknown when this will be available. I expect it to be available Spring 2018.

I have my genetic testing done. Where should I start?

Ask any winning coach where to start and they will say – “Start with the fundamentals.” There is no point to have genetic testing done if you have not yet done the basics. The basics are not taught unfortunately anywhere. My years of working with patients and professionals of all types worldwide has taught me which fundamentals are essential.

Consolidated into an easy-to-digest, do on your own time and practical collection of videos, the Dirty Genes Course is where you should start.

Access your genetic potential here via the Dirty Genes Course Bundle!

What other questions do you have? 

Share your thoughts and comments below and I will address them as they pertain to the new 23andMe v5 chip and genetic reporting.

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Comments 30

  1. Very good article, though I would appreciate some respect for your peers; I have all of their reports and used a geneticist and genetic nutritionist for 6 mos. And I adore Jess Armine.

    Getting tested for MTHFR saved my life after black mold incited it via ovarian cancer expression & I was put on antidepressants that nearly killed me.

    My homo c677t journey began, thanks to a CA psych who was learning to be food based. After he did only MTHFR, I did the rest and he allowed me to teach him. He especially liked the Walsh protocol for his practice. I have to teach docs all the time now as I can longer afford NDs. I have a epigenetic drug intolerance list that docs will not even touch though I finally found a CA trained one who accepts my NIH citations.

    I am the buoyant one in your wonderful epigenetic graphic; meditation and learning to let go and let God, have greatly helped and I now teach evidence based non-invasive epigenetics. Which part of my Stratagene shall I consider? I will ask on FB, too. I have a client I got onto Stratagene and he was kind enough to pre-order Dirty Genes for me.

    Do wish you could appreciate how hard we are all wanting to help each other. You remind me of “single theory” scientists when anyone who understands research understands nothing is ever “proven.” This truly is the age of epigenetics; all is flux and flow. Thanks for taking a stand on a very important issue. That a revolutionary company was sold to big pharma I find very disturbing as well as their published stance on MTHFR as extremely rare. Will be very interesting how extremely naive people will be pulled in to big med (watch youtube videos of people opening their reports btw). For this reason I support your strong stance. I do hope you come up with other options soon.

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      Hi Nancy –

      I do understand that many are working hard to help each other. I am all for it and encourage it.

      For years, I have been doing this research. I know what works and what doesn’t. I have to step up and now call out companies that are not doing what they should be or it will only perpetuate the misinformation that people get all. day. long.

      It has to stop.

      I am glad you are doing better and are actively learning and teaching others. It’s so needed.

      We will all get there. Collaborating is key as you said – but we also have to have the right information and tools or collaboration is all for not as no one will get better – and – sadly -they won’t know why because they ‘thought’ they had the right tools – and they didn’t.

      I have to step up and call them out.

      These other reporting companies can step up and produce a solid report.

      It’s their choice.

      I did call out ones that I respect – not just my own.

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  2. Thank you for the updated info. Looks like i3002468 is included after all.
    I hope that this new solution you are working on will be comprehensive, reasonably priced for the majority and available also for us in Europe.

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  3. Question on the topic of SNPs vs epigenetics. What is the correct way to interpret the apparent opposing concepts that, for example, MTHFR SNPs can yield 40% or 70% performance degradation if you happen to have the polymorphisms in question VS epigenetics which essentially states the environment is the main determinate of performance regardless of polymorphisms. Perhaps the answer is macro vs micro, where a SNP can have a discrete pathway impact but the SNP overall impact on the organism may lost in the noise of the environment’s dominant impact at the macro level. Is that the correct way to think of this?

    Thanks

    1. I should clarify that my use of the term environment above is used in the larger context where diet, exercise, mindset, and physical environment are all forms of an environment

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      Hi Dave – great comment.

      MTHFR SNPs MAY yield reduced performance – especially when:
      – low in riboflavin
      – hypothyroid
      – consuming folic acid

      MTHFR performance may reduce in performance – regardless of SNPs – especially when:
      – low in riboflavin
      – hypothyroid
      – consuming folic acid

      MTHFR performance may be awesome – regardless of SNPs – especially when:
      – riboflavin is adequate
      – thyroid function is good
      – consuming little to no folic acid

      So either way, MTHFR may be slowed via environment – just having the MTHFR SNP AMPLIFIES the environmental impact on the gene expression and enzymatic function.

      That’s how I look at it.

      This is a good resource to listen to – http://go.drbenlynch.com/fb-live-recap

  4. Dr. Lynch,
    I am glad to see that you have distanced yourself from MTHFR support. It seems that whenever there was a new report added, some genes polymorphisms suddenly became irrelevant and disappeared, while others, previously not a problem, suddenly became relevant. My feeling is if they are unsure of their research they should not have been more reports.
    Just my thoughts!
    Kathy Rice

  5. My aunt is APOE e3/e4 and has Alzheimer’s. She is also positive for biotoxin illness with the HLA DRB1… Testing for MTHFR is normally $300+ through LabCorp and Quest (Labcorp does have a discount to $160 if you pay for it upfront) and she needs to have that done and it doesn’t make sense to just have that done for that amount of money. So I’ve been looking into 23andMe and came accross this V5 chip snaffoo. So I have a few questions based on this article:

    1) You mentioned $99 for 23andMe. Does that mean you can just get the ancestry test done and the raw data is the same as getting the Health + Ancestry?

    2) Does your report give the same information (and of course more) as the 23andMe health report so that we could bypass getting that report done?

    3) What do you think of Nutrition Genome’s report (https://nutritiongenome.com/)?

    4) I’ve been in touch with Nutrition Genome and they still use the V4 chip for the genetic testing part. I asked if their data can be run through other reports such as Stratagene and they said that it was formatted in a way that other companies could use it. Would that be the case with Stratagene? If so, would that be a better test to have?

    I’ve been watching your videos and like your view on this and like the look of your reports. So I definitely want to run whichever data we get through Stratagene. I’m just very new at this and am trying to advise my family on the best, yet least expensive way to go and am feeling very inadequate and perplexed because of my limited knowledge.

    Thanks for any advice you may have!

    Mary

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        I do not approve of MTHFR Support report any longer. I used to support them until their recommendations are highly inaccurate as are their choices of SNPs. Many SNPs called on their report have little to no research.

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      Hi Mary –

      StrateGene will run whatever raw data you have from 23andMe. If your 23andMe is ordered after August 2017, then it is the V5 chip and will have a few SNPs missing from your StrateGene report.

      I have no idea who Nutrition Genome is.

      StrateGene only uses 23andMe raw data.

      I’m bias – but I will say StrateGene is leaps and bounds better than any other genetic report available because of the pathway analysis and epigenetic controls.

  6. Are you aware that 23andme does zero accuracy testing on their raw data? I have seen reports of those who have had to be retested through a real lab, and their results have not matched 23andme, and those that do.

    I see people who go by your recommendations, and yet, with no accuracy testing through 23andme , how can anyone trust their results?

    Are you an affiliate or in any way making commissions by recommending them?

    Are you making people aware that 23andme, as well as their “contracted lab” owns and sells our DNA? That they actually are not in the business of genetic testing and providing accurate results, but are providing some “health reports” and the raw data, simply to get more samples submitted so they can sell them to whomever they choose?

    There are so many issues with 23andme, and yet, people post online as if your recommendation is gospel.

    I think it would be a service to your followers, if you at least gave them the full picture of getting tested through a corporation rather than a real lab with accuracy testing.

    I appreciate your time and look forward to your response.

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      That is not what I heard – and no idea where you are getting this information. I verified with their chip maker directly and they have a highly refined chip.

      Am I making money with 23andMe? No. I do ‘make money’ with http://www.StrateGene.org which uses their raw data currently – but we working on changing that out.

      What makes you think a ‘real lab’ is more accurate than 23andMe? That’s crazy. Many labs are far from accurate. It’s a constant struggle finding quality lab testing companies and I’m highly considering forming one myself because I cannot get ones to meet my requirements.

      You have ‘reports’ – but not actual data.

      You also do not know who is wrong – 23andMe or the lab. I put my money on the labs being wrong – not 23andMe.

  7. I appreciate opportunity to ask questions. On the 23andMe website product comparison page, both options show raw data is included in service. However, they do give a qualifier not all data has been validated that appears concerning below: https://www.23andme.com/compare-dna-tests/
    “Access your raw, uninterpreted genetic data file.*** Must not be used for medical or diagnostic purposes.
    ***This data has undergone a general quality review however only a subset of
    markers have been individually validated for accuracy. The data from 23andMe’s Browse Raw Data feature is suitable only for research, educational, and informational use and not for medical, diagnostic or other use.” Two questions: 1) Without standard laboratory validation of all markers, can results be considered reliable? 2) Which 23and Me test product do you recommend? I was looking for an answer on your website, but do not see this question addressed.

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      the ancestry file is enough. I have run my genetics personally on many platforms. 23andMe is quite reliable. I have not personally seen any incorrect calls on their test. This doesn’t mean they don’t exist but I have not seen them nor heard of other health professionals I work with mention issues.

      I also talked with the makers of the DNA chip for 23andMe and they say their chip and processes are quite impressively accurate. Bias? Maybe – but at the same time I asked them about other companies using their chips and they said it depends. RE: 23andMe it’s pretty refined and tested.

  8. I habe down 23&me ans it is v5. Would I still get the info for the missing SNPs (what affects them) in the report or would I just get the info for the screened SNPs?

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  9. Hello. I am Towonia. Need your opinion please. My probable half sister (we believe we share a father) just tested after August using the v5 chip. Our shared CMs are 1275, 17.1% across 39 segments. Our X chromosome is not an identical match. My friend feels the gaps in the shared X Chromosom could be when there are genotyping problems. It could be that When i tested on 23andMe’s chip v3 or v4 (she is v5) has caused problems with the match’s chip v5 … Comparisons of both kits at Gedmatch should resolve the question of whether the X is shared in whole or in part… Usually (almost always) two half-SISTERS with the same father will share an identical X chromosome — this is because males have only one X-chromosome and it does not recombine with the Y and therefore he passes his X intact to all of his daughters.

  10. I’ve been looking at your site and trying to figure out if it’s necessary to get the Health + Ancestry report through 23andMe. They give a list of diseases and you give a list of snps that I don’t know which diseases they pertain to to be able to compare whether their report is covering things yours isn’t.

    I get that yours is better but does it cover what they cover as well? Is there a list that I can compare? Is there a full sample report that I can compare?

    Do you personally think there’s any value in getting the Health + Ancestry report along with yours?

    Thank you!

    Mary

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      Hi Mary –

      The Health report from 23andMe is not very valuable in my opinion.

      StrateGene does not cover what 23andme covers in their health report – it’s completely different.

      Personally I don’t think it’s necessary to get their health report.

      I don’t give a list of diseases with StrateGene – I rather show how the SNPs may impact the biochemical pathways.

  11. Dr. Lynch,

    We were fortunate to have gotten in on the ground floor with 23andMe price-wise and are just starting to realize how valuable the SNPs are for explaining why he continues to suffer from UC. Rather than assume similar genetics is causing my daughter’s issues, I guess I should test but Vitagene and Ancestry are more affordable (critical).

    Are you saying that we won’t get accuracy from those other labs?

    Thanks for chiming in,

    Lynn

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      I cannot say how accurate the other labs are – I just know that 23andMe is quite accurate. SNPs and genetics relating to UC aren’t really significant. UC is more an epigenetic condition.

  12. So I went a couple years convinced I had a MTHFR mutation based on my Mom’s family and her 9 miscarriages including two stillborns. Could not find one doctor in Western NY to run a test. Finally stumbled in a PA in an OBGYN office affiliated with a very conservative Medical School in Rochester, NY who was sending her self to A4M studying anti aging.. she offered to order all kinds of tests I could not get one other allopathic physician to run. Turns out I paid $99 to find out I don’t have one MTHFR variant. End of story? No two years later my raw data in hand, Strategene report and Boom there was the double MTRR which as it turns out is just as important as MTHFR Dr Ben I know you carried a lot of the credit for bringing MTHFR to light but you should really be talking about all the genes that impact methylation… the word is not getting out there. I have had many give me feedback one thing they disagreed with you over the years is your heavy emphasis one silo. Now I know you preach, don’t treat to one snp, and the new news it is about the cluster of genes and relevant rna. Anyway I appreciate your work and am slogging my way through the classes can’t wait for the book! Happy Holidays! ( your latest video on sugar was an eye opener.. and very timely for the season of excess)😌

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      Hi Kate –

      I’m glad you ordered StrateGene!

      This folic acid and pregnancy presentation focuses a lot on many pathways – and I talk about other folate genes – and also MTRR is in there as well.

      You’re right – needs to be made front and center.

      My next book is going to be on preconception / pregnancy…I’ll make it big news 😉

      Glad the sugar video helped!

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