If there is one thing constant in life, it’s change.
23andMe has a new version 5 chip which has the genetic reporting industry all up in arms.
Here are some common questions along with answers. Note that 23andMe may change how things are done at any time thereby rendering this entire article irrelevant.
Does 23andMe still test for MTHFR in the raw data?
Yes. Both MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) are there.
Can I access my raw data still?
Yes. You can access your raw data and download it as a .TXT file.
Which SNPs are missing from the new 23andme v5?
It depends on which genetic reporting tool you are using. Some reports are missing hundreds of SNPs. I say good riddance as most of those SNPs were likely irrelevant anyway. The presence of a SNP does not mean there is any variation of function – at all. People still are not getting this concept – and it is very frustrating.
The clinically-relevant SNPs no longer available in StrateGene:
rs72558181 MAT1A. This is quite rare anyhow in the population. Seeing how it is affected is possible in your StrateGene report. Testing for ‘Methionine’, ‘magnesium’ and ‘SAMe’ can be done to see if this gene is working as it should.
rs1799895 SOD3. Testing ‘lipid peroxidation’ can make up for this. Seeing how SOD is presented in StrateGene will offer some diagrammatic insights of how to support it.
rs1050450 GPX1. Testing ‘lipid peroxidation’ can make up for this. Test to see if your GPX is dirty here.
rs1800783 NOS3. If having cold hands and feet, that a dirty NOS3. Your StrateGene report will still provide Test to see if your NOS3 is dirty here.
i6018900 SULT1A1. This hasn’t been called for some time. You should avoid food coloring, preservatives anyhow.
rs6323 MAOA. This is a bummer. Easy questions can determine if this gene is dirty or not. Use your StrateGene report to still provide you diagrammatic insights on how it works with other genes. Check to see if your MAOA is dirty and what to do about it.
rs1137070. MAOA. Same as above.
rs1799836. MAOB. Use your ‘Histamine Pathway’ in your StrateGene report to see what you can do to support it. Seeing if your ‘riboflavin’ levels are sufficient is important here.
rs10156191. AOC1/ABP1/DAO. If you have histamine intolerance from food or drink, then this gene is dirty – period. You don’t need a SNP to tell you this. See if your DAO gene is dirty and how to clean it up.
rs2228570. VDR. This is a touchy SNP in the first place and the information in published research is conflicting. Read this to learn more about vitamin D.
- i3002468. HFE. Key here is to check your ‘serum ferritin’ and ‘TIBC’. This has to do with hemochromatosis which is quite common. Personally I have yet to see anyone with this SNP ++.
Should I order 23andMe still?
If you have not yet run 23andMe, you may still benefit from it if you are ok with not having the above SNPs in your results. It is still a good value for $99.
Is Ancestry.com a better option now?
No. I ran my Ancestry test and imported it into StrateGene. There were way more SNPs missing than 23andMe v5.
Which genetic testing reporting tool should I use?
I personally do not recommend using MTHFR Support, Livewello, Nutrahacker or Genetic Genie.
I do not agree with the SNPs they are calling as clinically-relevant nor do I agree with the recommendations provided.
StrateGene is the most researched, cited and actionable genetic testing report available. No it does not provide supplement recommendations. One cannot make recommendations based solely on a genetic report.
Promethease and Self Hacked are two other reporting companies that have researched information. Be cautious with any supplement recommendations made, however. I do not support that at all.
What is the long term solution?
I am currently working on a solution which will be vastly superior to both 23andMe and Ancestry. You can also be assured that it will maintain the strong clinically-relevant and published literature review requirements as the current StrateGene. The only difference? It will have more information and more relevant SNPs.
It is unknown when this will be available. I expect it to be available Spring 2018.
I have my genetic testing done. Where should I start?
Ask any winning coach where to start and they will say – “Start with the fundamentals.” There is no point to have genetic testing done if you have not yet done the basics. The basics are not taught unfortunately anywhere. My years of working with patients and professionals of all types worldwide has taught me which fundamentals are essential.
Consolidated into an easy-to-digest, do on your own time and practical collection of videos, the Dirty Genes Course is where you should start.
What other questions do you have?
Share your thoughts and comments below and I will address them as they pertain to the new 23andMe v5 chip and genetic reporting.