23andMe v5 Chip: What You Need to Know

Dr Lynch Featured 9 Comments

If there is one thing constant in life, it’s change.

23andMe has a new version 5 chip which has the genetic reporting industry all up in arms.

Here are some common questions along with answers. Note that 23andMe may change how things are done at any time thereby rendering this entire article irrelevant.

Does 23andMe still test for MTHFR in the raw data? 

Yes. Both MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) are there.

Can I access my raw data still?

Yes. You can access your raw data and download it as a .TXT file.

Which SNPs are missing from the new 23andme v5?

It depends on which genetic reporting tool you are using. Some reports are missing hundreds of SNPs. I say good riddance as most of those SNPs were likely irrelevant anyway. The presence of a SNP does not mean there is any variation of function – at all. People still are not getting this concept – and it is very frustrating.

The clinically-relevant SNPs no longer available in StrateGene:

  • rs72558181 MAT1A. This is quite rare anyhow in the population. Seeing how it is affected is possible in your StrateGene report. Testing for ‘Methionine’, ‘magnesium’ and ‘SAMe’ can be done to see if this gene is working as it should.

  • rs1799895 SOD3. Testing ‘lipid peroxidation’ can make up for this. Seeing how SOD is presented in StrateGene will offer some diagrammatic insights of how to support it.

  • rs1050450 GPX1. Testing ‘lipid peroxidation’ can make up for this. Test to see if your GPX is dirty here.

  • rs1800783 NOS3. If having cold hands and feet, that a dirty NOS3. Your StrateGene report will still provide  Test to see if your NOS3 is dirty here.

  • i6018900 SULT1A1. This hasn’t been called for some time. You should avoid food coloring, preservatives anyhow.

  • rs6323 MAOA. This is a bummer. Easy questions can determine if this gene is dirty or not. Use your StrateGene report to still provide you diagrammatic insights on how it works with other genes. Check to see if your MAOA is dirty and what to do about it.

  • rs1137070. MAOA. Same as above.

  • rs1799836. MAOB. Use your ‘Histamine Pathway’ in your StrateGene report to see what you can do to support it. Seeing if your ‘riboflavin’ levels are sufficient is important here.

  • rs10156191. AOC1/ABP1/DAO. If you have histamine intolerance from food or drink, then this gene is dirty – period. You don’t need a SNP to tell you this. See if your DAO gene is dirty and how to clean it up.

  • rs2228570. VDR. This is a touchy SNP in the first place and the information in published research is conflicting. Read this to learn more about vitamin D.

  • i3002468. HFE. Key here is to check your ‘serum ferritin’ and ‘TIBC’. This has to do with hemochromatosis which is quite common. Personally I have yet to see anyone with this SNP ++.

Should I order 23andMe still?

If you have not yet run 23andMe, you may still benefit from it if you are ok with not having the above SNPs in your results. It is still a good value for $99.

Is Ancestry.com a better option now?

No. I ran my Ancestry test and imported it into StrateGene. There were way more SNPs missing than 23andMe v5.

Which genetic testing reporting tool should I use?

I personally do not recommend using MTHFR Support, Livewello, Nutrahacker or Genetic Genie.

Why?

I do not agree with the SNPs they are calling as clinically-relevant nor do I agree with the recommendations provided.

StrateGene is the most researched, cited and actionable genetic testing report available. No it does not provide supplement recommendations. One cannot make recommendations based solely on a genetic report.

Promethease and Self Hacked are two other reporting companies that have researched information. Be cautious with any supplement recommendations made, however. I do not support that at all.

What is the long term solution?

I am currently working on a solution which will be vastly superior to both 23andMe and Ancestry. You can also be assured that it will maintain the strong clinically-relevant and published literature review requirements as the current StrateGene. The only difference? It will have more information and more relevant SNPs.

It is unknown when this will be available. I expect it to be available Spring 2018.

I have my genetic testing done. Where should I start?

Ask any winning coach where to start and they will say – “Start with the fundamentals.” There is no point to have genetic testing done if you have not yet done the basics. The basics are not taught unfortunately anywhere. My years of working with patients and professionals of all types worldwide has taught me which fundamentals are essential.

Consolidated into an easy-to-digest, do on your own time and practical collection of videos, the Dirty Genes Course is where you should start.

Access your genetic potential here via the Dirty Genes Course Bundle!

What other questions do you have? 

Share your thoughts and comments below and I will address them as they pertain to the new 23andMe v5 chip and genetic reporting.

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Comments 9

  1. Very good article, though I would appreciate some respect for your peers; I have all of their reports and used a geneticist and genetic nutritionist for 6 mos. And I adore Jess Armine.

    Getting tested for MTHFR saved my life after black mold incited it via ovarian cancer expression & I was put on antidepressants that nearly killed me.

    My homo c677t journey began, thanks to a CA psych who was learning to be food based. After he did only MTHFR, I did the rest and he allowed me to teach him. He especially liked the Walsh protocol for his practice. I have to teach docs all the time now as I can longer afford NDs. I have a epigenetic drug intolerance list that docs will not even touch though I finally found a CA trained one who accepts my NIH citations.

    I am the buoyant one in your wonderful epigenetic graphic; meditation and learning to let go and let God, have greatly helped and I now teach evidence based non-invasive epigenetics. Which part of my Stratagene shall I consider? I will ask on FB, too. I have a client I got onto Stratagene and he was kind enough to pre-order Dirty Genes for me.

    Do wish you could appreciate how hard we are all wanting to help each other. You remind me of “single theory” scientists when anyone who understands research understands nothing is ever “proven.” This truly is the age of epigenetics; all is flux and flow. Thanks for taking a stand on a very important issue. That a revolutionary company was sold to big pharma I find very disturbing as well as their published stance on MTHFR as extremely rare. Will be very interesting how extremely naive people will be pulled in to big med (watch youtube videos of people opening their reports btw). For this reason I support your strong stance. I do hope you come up with other options soon.

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      Author

      Hi Nancy –

      I do understand that many are working hard to help each other. I am all for it and encourage it.

      For years, I have been doing this research. I know what works and what doesn’t. I have to step up and now call out companies that are not doing what they should be or it will only perpetuate the misinformation that people get all. day. long.

      It has to stop.

      I am glad you are doing better and are actively learning and teaching others. It’s so needed.

      We will all get there. Collaborating is key as you said – but we also have to have the right information and tools or collaboration is all for not as no one will get better – and – sadly -they won’t know why because they ‘thought’ they had the right tools – and they didn’t.

      I have to step up and call them out.

      These other reporting companies can step up and produce a solid report.

      It’s their choice.

      I did call out ones that I respect – not just my own.

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      Author
  2. Thank you for the updated info. Looks like i3002468 is included after all.
    I hope that this new solution you are working on will be comprehensive, reasonably priced for the majority and available also for us in Europe.

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  3. Question on the topic of SNPs vs epigenetics. What is the correct way to interpret the apparent opposing concepts that, for example, MTHFR SNPs can yield 40% or 70% performance degradation if you happen to have the polymorphisms in question VS epigenetics which essentially states the environment is the main determinate of performance regardless of polymorphisms. Perhaps the answer is macro vs micro, where a SNP can have a discrete pathway impact but the SNP overall impact on the organism may lost in the noise of the environment’s dominant impact at the macro level. Is that the correct way to think of this?

    Thanks

    1. I should clarify that my use of the term environment above is used in the larger context where diet, exercise, mindset, and physical environment are all forms of an environment

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      Author

      Hi Dave – great comment.

      MTHFR SNPs MAY yield reduced performance – especially when:
      – low in riboflavin
      – hypothyroid
      – consuming folic acid

      MTHFR performance may reduce in performance – regardless of SNPs – especially when:
      – low in riboflavin
      – hypothyroid
      – consuming folic acid

      MTHFR performance may be awesome – regardless of SNPs – especially when:
      – riboflavin is adequate
      – thyroid function is good
      – consuming little to no folic acid

      So either way, MTHFR may be slowed via environment – just having the MTHFR SNP AMPLIFIES the environmental impact on the gene expression and enzymatic function.

      That’s how I look at it.

      This is a good resource to listen to – http://go.drbenlynch.com/fb-live-recap

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